WHSC2 (NELFA) (NM_005663) Human Untagged Clone

CAT#: SC327912

NELFA (untagged)-Human Wolf-Hirschhorn syndrome candidate 2 (WHSC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NELFA
• Synonyms: NELF-A; P/OKcl.15; WHSC2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005663, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCGGGGCAGCGGCGCGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGC
  TGCACAACAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGC
  GGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTCGGG
  ACGCTGCACCTCCCGCGCCGCACGGTGGACGAGATGAAGGGCGCCCTAATGGAGATCATCCAGCTCGCCA
  GCCTCGACTCGGACCCCTGGGTGCTCATGGTCGCCGACATCTTGAAGTCCTTTCCGGACACAGGCTCGCT
  TAACCTGGAGCTGGAGGAGCAGAATCCCAACGTTCAGGATATTTTGGGAGAACTTAGAGAAAAGGTGGGT
  GAGTGTGAAGCGTCTGCCATGCTGCCACTGGAGTGCCAGTACTTGAACAAAAACGCCCTGACGACCCTCG
  CGGGACCCCTCACTCCCCCGGTGAAGCATTTTCAGTTAAAGCGGAAACCCAAGAGCGCCACGCTGCGGGC
  GGAGCTGCTGCAGAAGTCCACGGAGACCGCCCAGCAGTTGAAGCGGAGCGCCGGGGTGCCCTTCCACGCC
  AAGGGCCGGGGGCTGCTGCGGAAGATGGACACCACCACCCCACTCAAAGGCATCCCGAAGCAGGCGCCCT
  TCAGAAGCCCCACGGCGCCCAGCGTCTTCAGCCCCACAGGGAACCGGACCCCCATCCCGCCTTCCAGGAC
  GCTGCTGCGGAAGGAACGAGGTGTGAAGCTGCTGGACATCTCTGAGCTGGATATGGTTGGCGCTGGCCGA
  GAGGCGAAGCGGAGAAGGAAGACTCTCGATGCGGAGGTGGTGGAGAAGCCGGCCAAGGAGGAAACGGTGG
  TGGAGAACGCCACCCCGGACTACGCAGCCGGCCTGGTGTCCACGCAGAAACTTGGGTCCCTGAACAATGA
  GCCTGCGCTGCCCTCCACGAGCTACCTTCCCTCCACGCCCAGCGTGGTTCCCGCCTCCTCCTACATCCCC
  AGCTCCGAGACGCCCCCAGCCCCATCTTCCCGGGAAGCCAGCCGCCCACCAGAGGAGCCCAGCGCCCCGA
  GCCCCACGTTGCCAGCGCAGTTCAAGCAGCGGGCGCCCATGTACAACAGCGGCCTGAGCCCTGCCACACC
  CACGCCTGCGGCGCCCACCTCGCCTCTGACACCCACCACACCTCCGGCTGTCGCCCCTACCACTCAGACA
  CCCCCGGTTGCCATGGTGGCCCCGCAGACCCAGGCCCCTGCTCAGCAGCAGCCTAAGAAGAACCTGTCCC
  TCACGAGAGAGCAGATGTTCGCTGCCCAGGAGATGTTCAAGACGGCCAACAAAGTCACGCGGCCCGAGAA
  GGCCCTCATCCTGGGCTTCATGGCCGGCTCCCGAGAGAACCCGTGCCAGGAGCAGGGGGACGTGATCCAG
  ATCAAGCTGAGCGAGCACACGGAGGACCTGCCCAAGGCGGACGGCCAGGGTAGCACAACCATGCTGGTGG
  ACACAGTGTTTGAGATGAACTATGCCACGGGCCAGTGGACGCGCTTCAAGAAGTACAAGCCCATGACCAA
  TGTGTCCTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_005663
• ORF Size: 1620 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005663.4, NP_005654.3
• RefSeq Size: 2479
• RefSeq ORF: 1620
• Locus ID: 7469
• Protein Families: Transcription Factors
• Gene Summary: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]