WHSC2 (NELFA) (NM_005663) Human Untagged Clone

CAT#: SC319082

NELFA (untagged)-Human Wolf-Hirschhorn syndrome candidate 2 (WHSC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NELFA
• Synonyms: NELF-A; P/OKcl.15; WHSC2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005663.2 CGCGCTTTCCCCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAA
  CAAGCTGGGGGCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGC
  CGCGGTCATCGACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAA
  GTTGCTACTCGGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGATGAAGGGCGCCCT
  AATGGAGATCATCCAGCTCGCCAGCCTCGACTCGGACCCCTGGGTGCTCATGGTCGCCGA
  CATCTTGAAGTCCTTTCCGGACACAGGCTCGCTTAACCTGGAGCTGGAGGAGCAGAATCC
  CAACGTTCAGGATATTTTGGGAGAACTTAGAGAAAAGGTGGGTGAGTGTGAAGCGTCTGC
  CATGCTGCCACTGGAGTGCCAGTACTTGAACAAAAACGCCCTGACGACCCTCGCGGGACC
  CCTCACTCCCCCGGTGAAGCATTTTCAGTTAAAGCGGAAACCCAAGAGCGCCACGCTGCG
  GGCGGAGCTGCTGCAGAAGTCCACGGAGACCGCCCAGCAGTTGAAGCGGAGCGCCGGGGT
  GCCCTTCCACGCCAAGGGCCGGGGGCTGCTGCGGAAGATGGACACCACCACCCCACTCAA
  AGGCATCCCGAAGCAGGCGCCCTTCAGAAGCCCCACGGCGCCCAGCGTCTTCAGCCCCAC
  AGGGAACCGGACCCCCATCCCGCCTTCCAGGACGCTGCTGCGGAAGGAACGAGGTGTGAA
  GCTGCTGGACATCTCTGAGCTGGATATGGTTGGCGCTGGCCGAGAGGCGAAGCGGAGAAG
  GAAGACTCTCGATGCGGAGGTGGTGGAGAAGCCGGCCAAGGAGGAAACGGTGGTGGAGAA
  CGCCACCCCGGACTACGCAGCCGGCCTGGTGTCCACGCAGAAACTTGGGTCCCTGAACAA
  TGAGCCTGCGCTGCCCTCCACGAGCTACCTTCCCTCCACGCCCAGCGTGGTTCCCGCCTC
  CTCCTACATCCCCAGCTCCGAGACACCCCCAGCCCCATCTTCCCGGGAAGCCAGCCGCCC
  ACCAGAGGAGCCCAGCGCCCCGAGCCCCACGTTGCCAGCGCAGTTCAAGCAGCGGGCGCC
  CATGTACAACAGCGGCCTGAGCCCTGCCACACCCACGCCTGCGGCGCCCACCTCGCCTCT
  GACACCCACCACACCTCCGGCTGTCGCCCCTACCACTCAGACACCCCCGGTTGCCATGGT
  GGCCCCGCAGACCCAGGCCCCTGCTCAGCAGCAGCCTAAGAAGAACCTGTCCCTCACGAG
  AGAGCAGATGTTCGCTGCCCAGGAGATGTTCAAGACGGCCAACAAAGTCACGCGGCCCGA
  GAAGGCCCTCATCCTGGGCTTCATGGCCGGCTCCCGAGAGAACCCGTGCCAGGAGCAGGG
  GGACGTGATCCAGATCAAGCTGAGCGAGCACACGGAGGACCTGCCCAAGGCGGACGGCCA
  GGGTAGCACAACCATGCTGGTGGACACAGTGTTTGAGATGAACTATGCCACGGGCCAGTG
  GACGCGCTTCAAGAAGTACAAGCCCATGACCAATGTGTCCTAGAACCACCTGCCTCACAG
  CTGGCCGTCACTTGTGGGGGTCCACGGGACGATGGCTTTGCCAGCTTAAAGTAACCGGAT
  GGCGGACACCTGGCCCCCGAGGTCCCCCGGCCGCCGCCCTGCTGCTGACCCAGCCTGTTT
  TAAGTTCTGGATGCATTTCTCTGGGGTATTTGGGGCTTATTTTTAAAATTTTAATATGGG
  TTCTTTTTTGTGTGATTTAAGACACTTTTTGGACTCAACGTTACATTTTTGAATGTAGTA
  AGTAAATTAACCAAAAAAGTTACAACTTCCTAATTTTAGTGACAGCTCTGCCTGTTAGAC
  TCTTACTTTTTAAAATCTTTTCTATTTTCCCTCGCTGGGGCAGTGCCCTCCTACCCCCAG
  GGTTGAGGGGACCAAGGTGGCACGGTGGTACTGGGGGTGCGGCAGGGACACCCGACCACA
  CCAGAGCGTGGGAGACGGTGGGCCTTGTCCCCTGCCTGTGCCTGCCTGGGAGTTTTGTAT
  TCATCTTTTGTATAGTTGTGGACATTTAAGACAGTCTTTGGGTACCTATTTTCATTGTAA
  AACTATCTGAACCATTAAAGTCGAGCTTTTCTAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005663.2 unedited
  GTACATTTGTATACGACTCCTATAGGGCGGCCGGGTAATTCGGCACGAGGCGCGCTTTCC
  CCCAAGATGGCGTCCATGCGGGAGAGCGACACGGGCCTGTGGCTGCACAACAAGCTGGGG
  GCCACGGACGAGCTGTGGGCGCCGCCCAGCATCGCGTCCCTGCTCACGGCCGCGGTCATC
  GACAACATCCGTCTCTGCTTCCATGGCCTCTCGTCGGCAGTGAAGCTCAAGTTGCTACTC
  GGGACGCTGCACCTCCCGCGCCGCACGGTGGACGAGATGAAGGGCGCCCTAATGGAGATC
  ATCCAGCTCGCCAGCCTCGACTCGGACCCCTGGGTGCTCATGGTCGCCGACATCTTGAAG
  TCCTTTCCGGACACAGGCTCGCTTAACCTGGAGCTGGAGGAGCAGAATCCCAACGTTCAG
  GATATTTTGGGAGAACTTAGAGAAAAGGTGGGTGAGTGTGAAGCGTCTGCCATGCTGCCA
  CTGGAGTGCCAGTACTTGAACAAAAACGCCCTGACGACCCTCGCGGGACCCCTCACTCCC
  CCGGTGAAGCATTTTCAGTTAAAGCGGAAACCCAAGAGCGCCACGCTGCGGGCGGAGCTG
  CTGCAGAAGTCCACGGAGACCGCCCAGCAGTTGAAGCGGAGCGCCGGGGTGCCCTTCCAC
  GCCAAGGGCCGGGGGCTGCTGCGGAAGATGGACACCACCACCCCACTCAAAGGCATCCCG
  AAGCAGCGCCCTTCAGAAGCCCCCACGGCGCCCAGCGTCTTCAGCCCCCACAGGGAACCG
  GACCCCCATCCCGCCTTCCAGGACGCTGCTGCGGAAGAACGAGTGTGAAGCTGCTGGACA
  TCTCTGAGCTGGATATGGTTGGCGCTGGCCGAGAGCGAAGCGGAGACGAGACTCTCGATG
  CGAGGTGTGGAGAAGCCGCCAAGAGAAACGGTGGGTGGGAGAACGCCCACCCCCGGACTA
  CGCCAGTCG
• Restriction Sites: Please inquire
• ACCN: NM_005663
• ORF Size: 1587 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005663.2, NP_005654.2
• RefSeq Size: 2466
• RefSeq ORF: 1587
• Locus ID: 7469
• Protein Families: Transcription Factors
• Gene Summary: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]