TXNRD3 (NM_001173513) Human Untagged Clone

CAT#: SC328978

TXNRD3 (untagged)-Human thioredoxin reductase 3 (TXNRD3) transcript variant 2 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)

Specifications

Product Data

• Type: Human Untagged Clone
• Symbol: TXNRD3
• Synonyms: TGR; TR2; TR2IT1; TRXR3; TXNRD3IT1; TXNRD3NB; TXNRD3NT1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001173513, the custom clone sequence may differ by one or more nucleotides
  
  
  CTGGAGCGGTCGCCGCCGCAGTCGCCCGGGCCGGGAAAGGCGGGCGATGCCCCCAACCGCCGCTCGGGCC
  ATGTCCGAGGGGCGCGCGTGTTGTCGCCGCCGGGGCGCCGTGCCCGCCTGTCGTCCCCCGGGCCCAGCCG
  CTCGTCCGAGGCCCGCGAGGAGCTGCGCCGCCACCTCGTGGGCCTCATCGAGCGCAGCCGGGTGGTGATC
  TTCAGCAAGAGCTACTGTCCCCATAGTACTCGGGTGAAAGAACTCTTTTCTTCTTTGGGAGTCGAATGTA
  ATGTCTTGGAACTTGATCAAGTTGATGATGGGGCCAGGGTTCAAGAAGTGCTGTCAGAAATCACTAATCA
  GAAAACTGTGCCCAATATTTTCGTGAATAAAGTGCATGTAGGTGGATGTGACCAAACTTTCCAGGCATAT
  CAGAGTGGTTTGTTACAGAAGCTCCTTCAGGAAGATTTGGCATATGATTATGATCTCATCATCATCGGTG
  GTGGTTCTGGAGGCCTTTCATGTGCGAAGGAAGCTGCCATTTTGGGAAAGAAAGTTATGGTGCTAGACTT
  TGTTGTCCCGTCACCTCAGGGCACATCCTGGGGTCTTGGTGGCACTTGTGTAAATGTAGGTTGTATTCCT
  AAGAAATTGATGCATCAGGCTGCCCTTTTGGGGCAGGCATTATGTGACTCAAGGAAATTTGGCTGGGAAT
  ATAATCAACAAGTGAGGCACAACTGGGAGACAATGACAAAAGCGATTCAGAACCACATCAGCTCTCTAAA
  CTGGGGCTACAGGTTGTCTCTGAGGGAAAAGGCTGTGGCCTATGTCAATTCCTATGGAGAATTTGTTGAA
  CATCATAAAATAAAGGCAACCAATAAAAAAGGACAGGAGACTTATTATACTGCTGCACAGTTTGTCATAG
  CAACGGGTGAAAGGCCACGGTATTTAGGAATCCAAGGAGATAAAGAATACTGTATTACTAGTGATGACCT
  TTTTTCTCTGCCTTATTGCCCTGGCAAAACATTAGTGGTGGGTGCCTCTTATGTTGCCCTGGAGTGTGCA
  GGGTTTCTGGCTGGCTTTGGCCTAGATGTCACAGTTATGGTACGCTCAATCCTTCTCCGTGGCTTCGACC
  AAGAAATGGCAGAAAAAGTGGGTTCCTACATGGAGCAGCATGGTGTGAAGTTCCTACGGAAATTCATACC
  TGTGATGGTTCAACAGTTGGAGAAAGGTTCACCTGGAAAGCTGAAAGTGTTGGCTAAATCCACTGAAGGA
  ACAGAAACAATTGAAGGAGTCTATAACACAGTTTTGTTAGCTATTGGTCGTGACTCCTGTACAAGGAAAA
  TAGGCTTGGAGAAGATTGGTGTCAAAATTAATGAGAAGAGTGGAAAAATACCTGTAAATGATGTGGAACA
  GACCAATGTGCCATATGTCTATGCTGTTGGTGATATTTTGGAGGATAAGCCAGAGCTCACTCCTGTCGCC
  ATACAGTCAGGCAAGCTGCTAGCTCAGAGACTTTTTGGGGCCTCTTTAGAAAAGATATATCATACTTTGT
  TCTGGCCTCTTGAATGGACAGTAGCTGGCAGAGAGAACAACACTTGTTACGCAAAGATAATCTGCAATAA
  ATTCGACCATGATCGGGTGATAGGATTTCATATTCTTGGACCAAACGCCGGTGAGGTTACCCAAGGATTT
  GCAGCTGCAATGAAATGTGGGCTCACAAAACAGCTACTTGATGACACCATTGGAATTCACCCCACATGTG
  GGGAGGTGTTCACGACTTTGGAAATCACAAAGTCGTCAGGACTAGACATCACTCAGAAAGGCTGCTGAGG
  CTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001173513
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.
• OTI Annotation: This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins.

Reference Data

• RefSeq: NM_001173513.1, NP_001166984.1
• RefSeq Size: 2811
• Locus ID: 114112
• Gene Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]
  Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1. A non-AUG (CUG) codon is used as translation initiation codon.