UNC45B (NM_001267052) Human Untagged Clone

CAT#: SC332839

UNC45B (untagged) - Homo sapiens unc-45 homolog B (C. elegans) (UNC45B), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UNC45B
• Synonyms: CMYA4; CTRCT43; SMUNC45; UNC-45B; UNC45
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001267052, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCAGAGGTGGAAGCGGTACAGCTGAAGGAGGAAGGAAACCGGCATTTCCAGCTCCAGGACTACAAGG
  CCGCCACAAATAGCTACAGCCAGGCCCTGAAGCTGACCAAGGACAAGGCCCTGCTGGCCACGCTTTATCG
  GAACCGGGCAGCCTGTGGCCTGAAAACGGAGAGCTACGTCCAGGCAGCTTCAGATGCCTCCAGAGCCATC
  GACATCAACTCCTCGGACATCAAGGCTCTGTATCGGCGATGCCAGGCACTGGAGCACCTGGGGAAGCTGG
  ACCAGGCCTTCAAAGACGTGCAGCGTTGTGCCACCCTCGAGCCACGGAACCAGAACTTCCAGGAGATGCT
  GAGGAGACTCAACACCAGCATTCAGGAGAAGCTCCGAGTGCAGTTCTCCACAGACTCGAGGGTACAGAAG
  ATGTTTGAGATCCTCTTGGATGAAAACAGTGAGGCTGATAAGCGGGAAAAGGCTGCCAACAATCTCATTG
  TCCTAGGCCGTGAGGAAGCAGGGGCTGAGAAGATCTTCCAGAACAATGGAGTAGCCTTGCTACTGCAGCT
  TCTGGACACTAAGAAGCCTGAGCTGGTGCTGGCTGCAGTGCGGACCCTGTCGGGCATGTGCAGCGGCCAC
  CAAGCCAGAGCCACAGTGATTCTGCATGCAGTGCGGATAGACCGAATCTGTAGCCTCATGGCCGTGGAGA
  ATGAGGAGATGTCTCTGGCTGTCTGCAACCTGCTCCAAGCCATCATTGACTCCTTGTCTGGGGAGGACAA
  GCGGGAGCATCGAGGGAAGGAGGAGGCCCTGGTTCTAGACACCAAGAAGGACCTGAAGCAGATCACCAGC
  CACCTGCTGGACATGCTAGTCAGCAAGAAGGTGTCTGGCCAGGGCAGGGATCAGGCGCTGAACCTGCTCA
  ATAAGAATGTTCCCAGGAAGGACCTTGCCATTCATGACAACTCACGTACCATCTATGTGGTGGATAATGG
  TCTGAGGAAGATCCTGAAGGTTGTGGGGCAGGTTCCAGATCTGCCATCCTGCCTGCCCCTGACTGACAAC
  ACCCGCATGCTGGCCTCTATCCTCATCAACAAGCTCTATGATGACCTGCGCTGTGACCCGGAGCGCGATC
  ACTTCCGCAAGATCTGTGAGGAATATATCACGGGCAAGTTTGACCCCCAGGACATGGACAAGAACTTGAA
  TGCCATCCAGACAGTGTCAGGGATCCTGCAGGGCCCCTTTGACCTGGGCAACCAGCTGCTGGGACTGAAA
  GGTGTGATGGAGATGATGGTGGCACTATGTGGCTCAGAGCGCGAGACGGACCAGCTGGTGGCCGTGGAGG
  CCCTCATCCATGCCTCCACGAAGCTCAGCCGCGCCACCTTCATCATCACCAATGGAGTGTCACTGCTCAA
  ACAGATCTACAAGACCACCAAAAATGAGAAGATCAAGATCCGCACACTGGTGGGACTCTGTAAGCTCGGC
  TCTGCAGGTGGCACAGACTACGGTCTCAGGCAGTTTGCGGAAGGGTCGACAGAAAAACTGGCCAAACAGT
  GTCGCAAGTGGCTGTGCAATATGTCCATAGACACTCGGACCCGACGCTGGGCAGTGGAGGGCCTGGCCTA
  CCTCACGCTGGACGCTGATGTGAAGGACGACTTTGTCCAGGACGTCCCTGCCCTGCAGGCCATGTTTGAG
  CTGGCCAAGACCAGTGACAAGACCATCCTGTACTCGGTGGCCACCACCCTGGTGAACTGCACCAACAGCT
  ACGATGTCAAGGAGGTCATCCCAGAGCTTGTCCAGCTCGCCAAGTTCTCCAAGCAGCATGTGCCCGAGGA
  ACACCCCAAGGACAAGAAGGACTTTATAGACATGCGGGTGAAGCGGCTTCTGAAGGCGGGTGTCATCTCT
  GCCCTGGCTTGCATGGTGAAAGCAGATAGTGCCATCCTCACTGACCAGACCAAGGAGCTGCTGGCCAGGG
  TATTCCTGGCACTGTGTGACAACCCAAAGGACCGAGGCACCATTGTGGCTCAAGGTGGTGGCAAGGCCCT
  GATTCCCCTGGCTTTGGAGGGCACAGATGTGGGCAAGGTGAAGGCAGCCCACGCTCTAGCAAAGATCGCT
  GCTGTCTCCAATCCGGACATTGCTTTTCCTGGGGAGCGGGTGTATGAGGTGGTGCGGCCCCTTGTAAGAC
  TCTTGGACACACAGAGGGATGGGCTTCAGAACTATGAGGCTCTCCTAGGCCTCACCAACCTGTCTGGGCG
  GAGTGACAAACTCCGGCAGAAGATCTTTAAGGAGAGGGCCTTGCCAGACATCGAGAACTACATGTTTGAG
  AATCATGATCAGCTGCGGCAGGCGGCCACCGAGTGCATGTGCAACATGGTGCTCCACAAGGAGGTACAGG
  AAAGGTTCTTGGCTGACGGGAATGACCGGCTGAAGCTGGTGGTGCTGCTCTGCGGGGAGGATGATGATAA
  GGTGCAGAATGCGGCTGCAGGGGCTCTGGCCATGCTGACAGCAGCACACAAGAAACTGTGCCTCAAGATG
  ACTCAAGTGACAACCCAGTGGTTGGAGATCCTCCAGCGGCTTTGCCTGCACGACCAGCTGTCTGTCCAAC
  ACCGGGGCCTGGTCATTGCCTACAACCTACTGGCAGCCGATGCTGAGCTGGCCAAGAAGCTGGTGGAGAG
  TGAGCTGCTGGAGATCCTGACTGTGGTGGGCAAACAGGAGCCAGATGAGAAGAAGGCAGAAGTGGTTCAG
  ACAGCCCGAGAATGTCTCATCAAGTGCATGGATTATGGTTTCATTAAACCAGTGTCTTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001267052
• ORF Size: 2790 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001267052.1, NP_001253981.1
• RefSeq Size: 5685
• RefSeq ORF: 2790
• Locus ID: 146862
• Gene Summary: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
  Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).