ERCC6 (NM_001277059) Human Untagged Clone

CAT#: SC333269

ERCC6-PGBD3 (untagged) - Homo sapiens ERCC6-PGBD3 readthrough (ERCC6-PGBD3), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ERCC6
• Synonyms: ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; POF11; RAD26; UVSS1
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001277059, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCCAAATGAGGGAATCCCCCACTCAAGTCAAACTCAGGAGCAAGACTGTTTACAGAGTCAACCTGTCA
  GTAATAATGAAGAAATGGCAATCAAGCAAGAAAGTGGTGGTGATGGGGAGGTGGAGGAGTACCTCTCCTT
  TCGTTCTGTGGGTGACGGGCTGTCCACCTCTGCTGTGGGGTGCGCATCAGCAGCTCCGAGGAGAGGGCCA
  GCCCTGCTGCACATCGACCGACATCAGATCCAGGCAGTAGAGCCTAGCGCCCAGGCCCTTGAGCTGCAGG
  GTTTGGGTGTGGACGTCTATGACCAGGACGTGCTGGAACAGGGAGTGCTTCAGCAGGTGGACAATGCCAT
  CCATGAGGCCAGCCGTGCCTCCCAGCTCGTTGACGTGGAGAAGGAGTATCGGTCGGTCCTGGATGACCTC
  ACGTCATGTACGACATCCCTAAGGCAAATCAATAAAATTATTGAACAGCTTAGCCCTCAAGCTGCCACCA
  GCAGAGACATCAACAGGAAACTAGATTCTGTAAAACGACAGAAGTATAATAAGGAACAACAGCTAAAAAA
  GATCACTGCAAAACAAAAGCATCTCCAGGCCATCCTTGGAGGAGCAGAGGTGAAAATTGAACTAGATCAC
  GCCAGTCTGGAGGAGGATGCAGAGCCGGGGCCATCCAGTCTTGGCAGCATGCTCATGCCTGTCCAGGAGA
  CTGCCTGGGAAGAGCTCATCCGCACTGGCCAGATGACACCTTTTGGTACCCAGATCCCTCAGAAACAGGA
  GAAAAAGCCCAGAAAAATCATGCTTAATGAAGCATCAGGCTTCGAAAAGTATTTGGCAGATCAAGCAAAA
  CTGTCTTTTGAAAGGAAGAAGCAAGGTTGTAATAAAAGAGCAGCTAGAAAAGCTCCAGCCCCAGTCACGC
  CTCCAGCCCCAGTGCAAAATAAAAACAAACCAAACAAGAAAGCCAGAGTTCTGTCCAAAAAAGAGGAGCG
  TTTGAAAAAGCACATCAAGAAACTCCAGAAGAGGGCTTTGCAGTTCCAGGGGAAAGTGGGATTGCCAAAG
  GCAAGGAGACCTTGGGAGTCAGACATGAGGCCAGAGGCAGAGGGAGACTCTGAGGGTGAAGAGTCTGAGT
  ATTTCCCCACAGAGGAGGAGGAAGAGGAGGAAGATGACGAGGTGGAGGGGGCAGAGGCGGACCTGTCTGG
  AGATGGTACTGACTATGAGCTGAAGCCTCTGCCCAAGGGCGGGAAACGGCAGAAGAAAGTGCCAGTGCAG
  GAGATTGATGATGACTTTTTCCCAAGTTCTGGGGAAGAAGCTGAAGCTGCTTCTGTAGGAGAAGGAGGAG
  GAGGAGGTCGGAAAGTGGGAAGATACCGAGATGATGGAGATGAAGATTATTATAAGCAGCGGTTAAGTCC
  CAAGATGCCTCGAACACTAAGTTTACATGAAATAACTGACCTTTTAGAGACAGATGACAGCATAGAAGCA
  AGTGCTATAGTGATACAACCACCTGAAAATGCTACAGCACCTGTTTCTGATGAGGAATCAGGAGATGAAG
  AAGGTGGAACAATAAATAATCTGCCAGGTTCTTTGTTGCACACAGCTGCGTATCTTATTCAAGATGGCTC
  TGATGCTGAGTCTGACTCAGATGATCCCTCATACGCACCTAAAGATGACTCTCCTGATGAAGTTCCATCT
  ACGTTTACTGTGCAGCAACCTCCACCATCAAGGAGGAGGAAAATGACAAAAATTCTTTGCAAATGGAAAA
  AAGCCGACCTAACTGTACAACCCGTAGCAGGTAGAGTTACAGCACCACCAAACGATTTCTTCACCGTAAT
  GAGAACTCCCACAGAAATTCTTGAACTTTTTCTTGATGACGAGGTCATTGAACTCATTGTCAAGTACTCC
  AACTTATATGCTTGCAGTAAAGGTGTACATCTTGGCTTGACTAGCTCTGAATTCAAATGTTTTCTGGGAA
  TTATTTTTCTGAGTGGTTATGTCTCAGTTCCTAGAAGGCGTATGTTTTGGGAACAAAGAACAGATGTGCA
  TAATGTACTGGTTAGTGCTGCCATGAGACGTGACCGGTTTGAAACTATATTTTCTAATTTGCATGTTGCT
  GACAATGCAAATTTGGATCCAGTGGACAAATTTTCCAAATTGCGACCTCTCATAAGCAAACTTAATGAGA
  GATGCATGAAATTTGTTCCAAATGAAACATATTTCAGCTTTGATGAATTCATGGTTCCTTATTTTGGTCG
  TCACGGGTGCAAACAATTTATTCGGGGAAAGCCCATTCGGTTTGGCTATAAGTTTTGGTGTGGTGCCACC
  TGTCTGGGCTACATTTGCTGGTTTCAGCCGTATCAGGGTAAAAACCCAAATACTAAACATGAGGAATATG
  GTGTCGGTGCGTCACTTGTCCTTCAGTTTAGTGAGGCACTTACAGAGGCACACCCTGGACAATACCATTT
  TGTATTCAATAACTTTTTCACCAGTATTGCACTTCTTGATAAGCTCAGTTCAATGGGACATCAGGCAACA
  GGTACAGTGAGAAAGGATCACATTGACAGAGTTCCACTGGAATCAGATGTAGCTTTAAAGAAAAAAGAAA
  GAGGCACATTTGATTATCGAATTGATGGCAAAGGCAATATTGTCTGCAGATGGAATGATAACAGTGTTGT
  CACTGTTGCCTCATCTGGTGCTGGTATCCATCCCCTGTGTCTTGTCAGTCGTTACTCCCAGAAACTGAAA
  AAGAAGATACAAGTTCAGCAGCCAAACATGATCAAAGTGTATAACCAGTTCATGGGAGGCGTAGACAGAG
  CTGATGAAAACATTGATAAGTATCGGGCATCAATCCGTGGAAAGAAATGGTATTCAAGCCCTCTTTTGTT
  CTGTTTCGAACTGGTCTTACAAAATGCTTGGCAATTGCATAAAACATATGATGAGAAACCAGTGGATTTT
  CTGGAGTTTCGTCGACGTGTGGTATGCCATTATCTGGAGACCCATGGTCATCCTCCAGAACCTGGCCAAA
  AAGGAAGACCTCAGAAGCGTAACATTGACTCACGTTATGATGGCATAAATCATGTGATAGTCAAACAGGG
  AAAGCAAACGCGATGCGCTGAATGTCATAAGAACACAACTTTTCGATGTGAAAAATGTGATGTTGCCTTA
  CATGTGAAGTGTTCCGTTGAATATCACACTGAATAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001277059
• ORF Size: 3186 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001277059.1, NP_001263988.1
• RefSeq Size: 3535
• RefSeq ORF: 3186
• Locus ID: 101243544
• Protein Families: Druggable Genome
• Protein Pathways: Nucleotide excision repair
• Gene Summary: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016]
  Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate 3' terminal exon, compared to variant 3. It is generated as a result of splicing of ERCC6 exon 5 to the 3' splice site upstream of the PGBD3 ORF that activates the alternative polyadenylation site downstream of the PGBD3 ORF. The resulting protein (isoform 1, ERCC6-PGBD3 fusion protein) is shorter and has a distinct C-terminus, compared to isoform 2.