TAB2 (NM_001292035) Human Untagged Clone

CAT#: SC337141

TAB2 (untagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TAB2
• Synonyms: CHTD2; MAP3K7IP2; TAB-2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001292035, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTATG
  GTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAA
  CTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACT
  CTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCAGCAGGAGC
  CACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTTGGAATGTCCAGTTCCTCTGGTGCTTC
  AAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATCTAGCCTTTCTCAACAAACTCCC
  AGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACATCTTTGC
  ACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACAT
  TACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATG
  AACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCTGCATCTAATCCTCTGT
  CACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACATGCCAATCAGTTC
  ACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCTCACAGTCTTCTGCCCATAGCCAATAT
  AACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGAAATCAAACTTGAACCCCCACAAAGAA
  ATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGCACTTCCTCTTCAGTCAATAGCCAGAC
  CTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGATGAGCTGATGTCCCGT
  AGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTCATGCGGAATCAGCCCA
  CACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGGAACATGTCTGGGCAAGTGAGCATGGG
  TCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAGGCAATAACTCTGCAACCTCTCCTCGA
  GTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTACAGTCTCTCCCAATAAGCCCCCTGCAG
  TTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTTCTTAATCATCCTGATCATTATGTAGA
  AACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGATAGAATAAGTGAAACACGGAAA
  CTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTTGGTACACCAGAAGGCCAGAATGGAAC
  GACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTAAAATCTGAGGTTAATGAAATGGA
  AAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCCCAGATACCTTCCCTTGAAGAAATG
  CAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGACTGCTTAACCAAAGAAATTGATCTTT
  TTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAACTTTTATGACAATATTGGATTTGTAGG
  TCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAACACCAAAGACTCAAGACACAGAAGAT
  GATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAACCATCCAGCCTTAATTCGCTGTGAAC
  AGTGTGAGATGCCAAGGCATTTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001292035
• ORF Size: 1986 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001292035.2, NP_001278964.1
• RefSeq Size: 4206
• RefSeq ORF: 1986
• Locus ID: 23118
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
  Transcript Variant: This variant (4) contains an alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.