TAB2 (NM_001292034) Human Untagged Clone

CAT#: SC337216

TAB2 (untagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TAB2
• Synonyms: CHTD2; MAP3K7IP2; TAB-2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001292034, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGTAC
  CTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTC
  TCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGT
  CTACGCAATCACATGACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAG
  GAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTC
  CAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTT
  GGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAA
  CATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGAC
  TGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGA
  AATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTG
  GCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGAC
  TACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACC
  TCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCT
  CACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGA
  AATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGC
  ACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCC
  CAAATACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGA
  TGAACAGGTCATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG
  AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAG
  GCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTAC
  AGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTT
  CTTAATCATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATG
  TGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTT
  GGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAA
  TTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATAT
  CCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGA
  CTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAAC
  TTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAA
  CACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAA
  CCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001292034
• ORF Size: 2082 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_001292034.2, NP_001278963.1
• RefSeq Size: 4171
• RefSeq ORF: 2082
• Locus ID: 23118
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
  Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).