Icos (NM_017480) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR202040L4V

Lenti ORF particles, Icos (GFP-tagged) - Mouse inducible T-cell co-stimulator (Icos), 200ul, >10^7 TU/mL

Product Images

MR202040L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR202040L4V particle to overexpress human Icos-mGFP fusion protein.

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Icos
• Synonyms: AILIM; CCLP; CRP-1; H4; Ly115
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_017480
• ORF Size: 603 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR202040).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_017480.1
• RefSeq Size: 3272 bp
• RefSeq ORF: 603 bp
• Locus ID: 54167
• UniProt ID: Q9WVS0
• Cytogenetics: 1 30.6 cM
• Gene Summary: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).[UniProtKB/Swiss-Prot Function]