Cd40lg (NM_011616) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR226279L4V

Lenti ORF particles, Cd40lg (GFP-tagged) - Mouse CD40 ligand (Cd40lg), 200ul, >10^7 TU/mL

Product Images

MR226279L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR226279L4V particle to overexpress human Cd40lg-mGFP fusion protein.

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Cd40lg
• Synonyms: CD40-L; Cd40l; CD154; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; Tnlg8b; TRAP
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_011616
• ORF Size: 780 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR226279).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_011616.2, NP_035746.2
• RefSeq Size: 1250 bp
• RefSeq ORF: 783 bp
• Locus ID: 21947
• UniProt ID: P27548
• Cytogenetics: X 31.21 cM
• Gene Summary: Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (PubMed:1374165).[UniProtKB/Swiss-Prot Function]