Sirpa (NM_007547) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR226909L4V

Lenti ORF particles, Sirpa (GFP-tagged) - Mouse signal-regulatory protein alpha (Sirpa), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

MR226909L4 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with MR226909L4V particle to overexpress human Sirpa-mGFP fusion protein.

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Sirpa
• Synonyms: AI835480; Bit; CD172a; P84; Ptpns1; SHP-1; SHPS-1; SIRP
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_007547
• ORF Size: 1527 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR226909).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_007547.4, NP_031573.2
• RefSeq Size: 4031 bp
• RefSeq ORF: 1530 bp
• Locus ID: 19261
• UniProt ID: P97797
• Cytogenetics: 2 63.19 cM
• Gene Summary: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).[UniProtKB/Swiss-Prot Function]