Cardiac Troponin I (TNNC1) (NM_003280) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC207014L1V

Lenti ORF particles, TNNC1 (Myc-DDK tagged) - Human troponin C type 1 (slow) (TNNC1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: TNNC1
• Synonyms: CMD1Z; CMH13; TN-C; TNC; TNNC
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_003280
• ORF Size: 483 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207014).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_003280.1, NP_003271.1
• RefSeq Size: 705 bp
• RefSeq ORF: 486 bp
• Locus ID: 7134
• Cytogenetics: 3p21.1
• Domains: EFh
• Protein Pathways: Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
• MW: 18.4 kDa
• Gene Summary: 'Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]'