KPNA2 (NM_002266) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC208803L2V

Lenti ORF particles, KPNA2 (mGFP-tagged) - Human karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: KPNA2
• Synonyms: IPOA1; QIP2; RCH1; SRP1-alpha; SRP1alpha
• Vector: pLenti-C-mGFP
• ACCN: NM_002266
• ORF Size: 1587 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208803).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002266.2, NP_002257.1
• RefSeq Size: 2011 bp
• RefSeq ORF: 1590 bp
• Locus ID: 3838
• Cytogenetics: 17q24.2
• Domains: Armadillo_seg, IBB
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• MW: 57.9 kDa
• Gene Summary: 'The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]'