HTR2B (NM_000867) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC209364L1V

Lenti ORF particles, HTR2B (Myc-DDK tagged) - Human 5-hydroxytryptamine (serotonin) receptor 2B (HTR2B), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: HTR2B
• Synonyms: 5-HT(2B); 5-HT-2B; 5-HT2B
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_000867
• ORF Size: 1443 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209364).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000867.2, NP_000858.2
• RefSeq Size: 2260 bp
• RefSeq ORF: 1446 bp
• Locus ID: 3357
• Cytogenetics: 2q37.1
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Gap junction, Neuroactive ligand-receptor interaction
• MW: 54.1 kDa
• Gene Summary: 'This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]'