DNA Ligase I (LIG1) (NM_000234) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210760L1V

Lenti ORF particles, LIG1 (Myc-DDK tagged) - Human ligase I, DNA, ATP-dependent (LIG1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: LIG1
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_000234
• ORF Size: 2757 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210760).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000234.1, NP_000225.1
• RefSeq Size: 3083 bp
• RefSeq ORF: 2760 bp
• Locus ID: 3978
• Cytogenetics: 19q13.33
• Domains: DNA_ligase
• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair
• MW: 101.6 kDa
• Gene Summary: 'This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'