POLE (NM_006231) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC224742L1V

Lenti ORF particles, POLE (Myc-DDK tagged) - Human polymerase (DNA directed), epsilon (POLE), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: POLE
• Synonyms: CRCS12; FILS; IMAGEI; POLE1
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_006231
• ORF Size: 6858 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224742).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_006231.2, NP_006222.2
• RefSeq Size: 7859 bp
• RefSeq ORF: 6861 bp
• Locus ID: 5426
• Cytogenetics: 12q24.33
• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair, DNA replication, Metabolic pathways, Nucleotide excision repair, Purine metabolism, Pyrimidine metabolism
• MW: 261.3 kDa
• Gene Summary: 'This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]'