Human ADA activation kit by CRISPRa

CAT#: GA100064

ADA CRISPRa kit - CRISPR gene activation of human adenosine deaminase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADA
• Locus ID: 100
• Kit Components:

  GA100064G1, ADA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100064G2, ADA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100064G3, ADA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000022, NM_001322050, NM_001322051, NR_136160
• Synonyms: adenosine aminohydrolase; adenosine deaminase
• Summary: 'This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunity. Conversely, elevated levels of this enzyme are associated with congenital hemolytic anemia. [provided by RefSeq, Sep 2019]'