Human AP2 alpha (AP2A1) activation kit by CRISPRa

CAT#: GA100113

AP2A1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 2 subunit alpha 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AP2A1
• Locus ID: 160
• Kit Components:

  GA100113G1, AP2 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100113G2, AP2 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100113G3, AP2 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014203, NM_130787
• Synonyms: ADTAA; AP2-ALPHA; CLAPA1
• Summary: 'This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]'