Human Amino terminal enhancer of split (AES) activation kit by CRISPRa

CAT#: GA100119

TLE5 CRISPRa kit - CRISPR gene activation of human TLE family member 5, transcriptional modulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TLE5
• Locus ID: 166
• Kit Components:

  GA100119G1, Amino terminal enhancer of split gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100119G2, Amino terminal enhancer of split gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100119G3, Amino terminal enhancer of split gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130, NM_198969, NM_198970, N23852
• Synonyms: AES-1; AES-2; ESP1; GRG; Grg-5; GRG5; TLE5
• Summary: 'The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'