Human AKR1B1 activation kit by CRISPRa

CAT#: GA100164

AKR1B1 CRISPRa kit - CRISPR gene activation of human aldo-keto reductase family 1 member B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AKR1B1
• Locus ID: 231
• Kit Components:

  GA100164G1, AKR1B1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100164G2, AKR1B1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100164G3, AKR1B1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001628, NM_001346142, NR_144376
• Synonyms: ADR; ALDR1; ALR2; AR
• Summary: 'This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]'