Human Beta Arrestin 2 (ARRB2) activation kit by CRISPRa

CAT#: GA100298

ARRB2 CRISPRa kit - CRISPR gene activation of human arrestin beta 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARRB2
• Locus ID: 409
• Kit Components:

  GA100298G1, Beta Arrestin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100298G2, Beta Arrestin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100298G3, Beta Arrestin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001257328, NM_001257329, NM_001257330, NM_001257331, NM_004313, NM_199004, NR_047516, NM_001330064
• Synonyms: ARB2; ARR2; BARR2
• Summary: 'Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]'