Human ATM activation kit by CRISPRa

CAT#: GA100329

ATM CRISPRa kit - CRISPR gene activation of human ATM serine/threonine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATM
• Locus ID: 472
• Kit Components:

  GA100329G1, ATM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100329G2, ATM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100329G3, ATM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000051, NM_138292, NM_138293, NM_001351834, NM_001351835, NM_001351836
• Synonyms: AT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
• Summary: 'The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]'