Human SERCA3 (ATP2A3) activation kit by CRISPRa

CAT#: GA100344

ATP2A3 CRISPRa kit - CRISPR gene activation of human ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATP2A3
• Locus ID: 489
• Kit Components:

  GA100344G1, SERCA3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100344G2, SERCA3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100344G3, SERCA3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005173, NM_174953, NM_174954, NM_174955, NM_174956, NM_174957, NM_174958
• Synonyms: SERCA3
• Summary: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]