Human C2 activation kit by CRISPRa

CAT#: GA100497

C2 CRISPRa kit - CRISPR gene activation of human complement C2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: C2
• Locus ID: 717
• Kit Components:

  GA100497G1, C2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100497G2, C2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100497G3, C2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000063, NM_001145903, NM_001178063, NM_001282457, NM_001282458, NM_001282459, NR_073063, N63977, NM_001282459.2, NM_001282457.2, NM_001282458.2
• Synonyms: ARMD14; CO2
• Summary: 'Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]'