Human CACNA2D1 activation kit by CRISPRa

CAT#: GA100546

CACNA2D1 CRISPRa kit - CRISPR gene activation of human calcium voltage-gated channel auxiliary subunit alpha2delta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CACNA2D1
• Locus ID: 781
• Kit Components:

  GA100546G1, CACNA2D1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100546G2, CACNA2D1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100546G3, CACNA2D1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000722, NM_001302890, NM_001366867, NM_001302890.2
• Synonyms: CACNA2; CACNL2A; CCHL2A; LINC01112; lncRNA-N3
• Summary: 'The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]'