Human Calpain 1 (CAPN1) activation kit by CRISPRa

CAT#: GA100576

CAPN1 CRISPRa kit - CRISPR gene activation of human calpain 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAPN1
• Locus ID: 823
• Kit Components:

  GA100576G1, Calpain 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100576G2, Calpain 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100576G3, Calpain 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001198868, NM_001198869, NM_001198870, NM_005186, NR_040008
• Synonyms: CANP; CANP1; CANPL1; muCANP; muCL; SPG76
• Summary: 'The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]'