Human Caveolin 3 (CAV3) activation kit by CRISPRa

CAT#: GA100603

CAV3 CRISPRa kit - CRISPR gene activation of human caveolin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CAV3
• Locus ID: 859
• Kit Components:

  GA100603G1, Caveolin 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100603G2, Caveolin 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100603G3, Caveolin 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001234, NM_033337
• Synonyms: LGMD1C; LQT9; VIP-21; VIP21
• Summary: 'This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]'