Human CCBL1 (KYAT1) activation kit by CRISPRa

CAT#: GA100619

KYAT1 CRISPRa kit - CRISPR gene activation of human kynurenine aminotransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KYAT1
• Locus ID: 883
• Kit Components:

  GA100619G1, CCBL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100619G2, CCBL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100619G3, CCBL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001122671, NM_001122672, NM_001287390, NM_004059, NR_109829, NM_001352988, NM_001352989, NM_001352990, NM_001352991, NM_001352992, NM_001352993, NM_001352994, NM_001352995, NM_001352996, NM_001352997, NM_001352998, NM_001352999, NR_148224, NR_148225, NM_001287390.2
• Synonyms: CCBL1; GTK; KAT1; KATI
• Summary: 'This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]'