Human Cyclin T2 (CCNT2) activation kit by CRISPRa

CAT#: GA100635

CCNT2 CRISPRa kit - CRISPR gene activation of human cyclin T2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCNT2
• Locus ID: 905
• Kit Components:

  GA100635G1, Cyclin T2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100635G2, Cyclin T2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100635G3, Cyclin T2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001241, NM_001320748, NM_001320749, NM_058241, NR_037649, NR_135468
• Synonyms: CYCT2
• Summary: 'The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]'