Human Liver Carboxylesterase 1 (CES1) activation kit by CRISPRa

CAT#: GA100768

CES1 CRISPRa kit - CRISPR gene activation of human carboxylesterase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CES1
• Locus ID: 1066
• Kit Components:

  GA100768G1, Liver Carboxylesterase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100768G2, Liver Carboxylesterase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100768G3, Liver Carboxylesterase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001025194, NM_001025195, NM_001266
• Synonyms: ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
• Summary: 'This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]'