Human CLCN1 activation kit by CRISPRa

CAT#: GA100842

CLCN1 CRISPRa kit - CRISPR gene activation of human chloride voltage-gated channel 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLCN1
• Locus ID: 1180
• Kit Components:

  GA100842G1, CLCN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100842G2, CLCN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100842G3, CLCN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000083, NR_046453
• Synonyms: CLC1
• Summary: 'The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]'