Human CLCNKB activation kit by CRISPRa

CAT#: GA100850

CLCNKB CRISPRa kit - CRISPR gene activation of human chloride voltage-gated channel Kb

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLCNKB
• Locus ID: 1188
• Kit Components:

  GA100850G1, CLCNKB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100850G2, CLCNKB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100850G3, CLCNKB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000085, NM_001165945
• Synonyms: ClC-K2; ClC-Kb; CLCKB
• Summary: 'The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]'