Human Collagen VI (COL6A1) activation kit by CRISPRa

CAT#: GA100905

COL6A1 CRISPRa kit - CRISPR gene activation of human collagen type VI alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL6A1
• Locus ID: 1291
• Kit Components:

  GA100905G1, Collagen VI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100905G2, Collagen VI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100905G3, Collagen VI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001848
• Synonyms: BTHLM1; OPLL; UCHMD1
• Summary: 'The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. [provided by RefSeq, Jul 2008]'