Human COX8A activation kit by CRISPRa

CAT#: GA100942

COX8A CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase subunit 8A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COX8A
• Locus ID: 1351
• Kit Components:

  GA100942G1, COX8A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100942G2, COX8A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100942G3, COX8A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004074
• Synonyms: COX; COX8; COX8-2; COX8L; VIII; VIII-L
• Summary: The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]