Human Carboxypeptidase B2 (CPB2) activation kit by CRISPRa

CAT#: GA100951

CPB2 CRISPRa kit - CRISPR gene activation of human carboxypeptidase B2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CPB2
• Locus ID: 1361
• Kit Components:

  GA100951G1, Carboxypeptidase B2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100951G2, Carboxypeptidase B2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100951G3, Carboxypeptidase B2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278541, NM_001872, NM_016413
• Synonyms: CPU; PCPB; TAFI
• Summary: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]