Human CRKL activation kit by CRISPRa

CAT#: GA100984

CRKL CRISPRa kit - CRISPR gene activation of human CRK like proto-oncogene, adaptor protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRKL
• Locus ID: 1399
• Kit Components:

  GA100984G1, CRKL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100984G2, CRKL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100984G3, CRKL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005207, NR_156180
• Synonyms: v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like
• Summary: 'This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]'