Human delta 2 Catenin (CTNND2) activation kit by CRISPRa

CAT#: GA101062

CTNND2 CRISPRa kit - CRISPR gene activation of human catenin delta 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTNND2
• Locus ID: 1501
• Kit Components:

  GA101062G1, delta 2 Catenin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101062G2, delta 2 Catenin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101062G3, delta 2 Catenin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001288715, NM_001288716, NM_001288717, NM_001332, NR_109988, NM_001364128
• Synonyms: GT24; NPRAP
• Summary: 'This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]'