Human CYP1B1 activation kit by CRISPRa

CAT#: GA101092

CYP1B1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 1 subfamily B member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP1B1
• Locus ID: 1545
• Kit Components:

  GA101092G1, CYP1B1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101092G2, CYP1B1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101092G3, CYP1B1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000104
• Synonyms: CP1B; CYPIB1; GLC3A; P4501B1
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]'