Human Aromatase (CYP19A1) activation kit by CRISPRa

CAT#: GA101117

CYP19A1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 19 subfamily A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP19A1
• Locus ID: 1588
• Kit Components:

  GA101117G1, Aromatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101117G2, Aromatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101117G3, Aromatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000103, NM_031226, NM_001347248, NM_001347249, NM_001347250, NM_001347251, NM_001347252, NM_001347253, NM_001347254, NM_001347255, NM_001347256
• Synonyms: ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]'