Human DAD1 activation kit by CRISPRa

CAT#: GA101127

DAD1 CRISPRa kit - CRISPR gene activation of human defender against cell death 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DAD1
• Locus ID: 1603
• Kit Components:

  GA101127G1, DAD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101127G2, DAD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101127G3, DAD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001344
• Synonyms: OST2
• Summary: 'DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]'