Human DIAPH1 activation kit by CRISPRa

CAT#: GA101199

DIAPH1 CRISPRa kit - CRISPR gene activation of human diaphanous related formin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DIAPH1
• Locus ID: 1729
• Kit Components:

  GA101199G1, DIAPH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101199G2, DIAPH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101199G3, DIAPH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079812, NM_001314007, NM_005219
• Synonyms: DFNA1; DIA1; DRF1; hDIA1; LFHL1
• Summary: 'This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'