Human DNase II (DNASE2) activation kit by CRISPRa

CAT#: GA101236

DNASE2 CRISPRa kit - CRISPR gene activation of human deoxyribonuclease 2, lysosomal

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNASE2
• Locus ID: 1777
• Kit Components:

  GA101236G1, DNase II gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101236G2, DNase II gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101236G3, DNase II gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001375
• Synonyms: DNASE2A; DNL; DNL2
• Summary: 'This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]'