Human DNMT3A activation kit by CRISPRa

CAT#: GA101244

DNMT3A CRISPRa kit - CRISPR gene activation of human DNA methyltransferase 3 alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNMT3A
• Locus ID: 1788
• Kit Components:

  GA101244G1, DNMT3A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101244G2, DNMT3A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101244G3, DNMT3A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320892, NM_001320893, NM_022552, NM_153759, NM_175629, NM_175630, NR_135490
• Synonyms: DNMT3A2; M.HsaIIIA; TBRS
• Summary: 'CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]'