Human OVCA1 (DPH1) activation kit by CRISPRa

CAT#: GA101254

DPH1 CRISPRa kit - CRISPR gene activation of human diphthamide biosynthesis 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DPH1
• Locus ID: 1801
• Kit Components:

  GA101254G1, OVCA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101254G2, OVCA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101254G3, OVCA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001383, NM_001346574, NM_001346575, NM_001346576, NR_144474, NR_144475, NR_144476
• Synonyms: DPH2L; DPH2L1; OVCA1
• Summary: 'The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016]'