Human MARK2 activation kit by CRISPRa

CAT#: GA101394

MARK2 CRISPRa kit - CRISPR gene activation of human microtubule affinity regulating kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MARK2
• Locus ID: 2011
• Kit Components:

  GA101394G1, MARK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101394G2, MARK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101394G3, MARK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039468, NM_001039469, NM_001163296, NM_001163297, NM_004954, NM_017490
• Synonyms: ELKL motif kinase 1; EMK1; MAP/microtubule affinity-regulating kinase 2; MGC99619; PAR-1; Par1b; protein-serine/threonine kinase; Ser/Thr protein kinase PAR-1B; serine/threonine kinase
• Summary: 'This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]'