MARK2 Human Gene Knockout Kit (CRISPR)

CAT#: KN410279

MARK2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

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Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: MARK2
• Locus ID: 2011
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001039468, NM_001039469, NM_001163296, NM_001163297, NM_004954, NM_017490
• Synonyms: ELKL motif kinase 1; EMK1; MAP/microtubule affinity-regulating kinase 2; MGC99619; PAR-1; Par1b; protein-serine/threonine kinase; Ser/Thr protein kinase PAR-1B; serine/threonine kinase
• Summary: 'This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]'