Human XPD (ERCC2) activation kit by CRISPRa

CAT#: GA101445

ERCC2 CRISPRa kit - CRISPR gene activation of human ERCC excision repair 2, TFIIH core complex helicase subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERCC2
• Locus ID: 2068
• Kit Components:

  GA101445G1, XPD gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101445G2, XPD gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101445G3, XPD gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000400, NM_001130867
• Synonyms: COFS2; EM9; TFIIH; TTD; TTD1; XPD
• Summary: 'The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'