Human CSB (ERCC6) activation kit by CRISPRa

CAT#: GA101451

ERCC6 CRISPRa kit - CRISPR gene activation of human ERCC excision repair 6, chromatin remodeling factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ERCC6
• Locus ID: 2074
• Kit Components:

  GA101451G1, CSB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101451G2, CSB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101451G3, CSB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000124, NM_001277058, NM_001277059, NM_001346440
• Synonyms: ARMD5; CKN2; COFS; COFS1; CSB; RAD26; UVSS1
• Summary: 'This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016]'