Human ACSL3 activation kit by CRISPRa

CAT#: GA101522

ACSL3 CRISPRa kit - CRISPR gene activation of human acyl-CoA synthetase long chain family member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACSL3
• Locus ID: 2181
• Kit Components:

  GA101522G1, ACSL3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101522G2, ACSL3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101522G3, ACSL3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004457, NM_203372, NM_001354158, NM_001354159, N44998
• Synonyms: ACS3; FACL3; PRO2194
• Summary: 'The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'