Human Fibroblast activation protein, alpha (FAP) activation kit by CRISPRa

CAT#: GA101530

FAP CRISPRa kit - CRISPR gene activation of human fibroblast activation protein alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FAP
• Locus ID: 2191
• Kit Components:

  GA101530G1, Fibroblast activation protein, alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101530G2, Fibroblast activation protein, alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101530G3, Fibroblast activation protein, alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291807, NM_004460
• Synonyms: DPPIV; FAPA; SIMP
• Summary: 'The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]'