Human Fibrinogen alpha chain (FGA) activation kit by CRISPRa

CAT#: GA101566

FGA CRISPRa kit - CRISPR gene activation of human fibrinogen alpha chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGA
• Locus ID: 2243
• Kit Components:

  GA101566G1, Fibrinogen alpha chain gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101566G2, Fibrinogen alpha chain gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101566G3, Fibrinogen alpha chain gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000508, NM_021871
• Synonyms: Fib2
• Summary: 'This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]'